Intercalative Stacking: A Critical Feature of DNA Charge-Transport Electrochemistry
نویسندگان
چکیده
منابع مشابه
Stacking interactions and intercalative DNA binding.
The DNA-binding properties of many ligands can be rationalized on the basis of their structural and electronic complementarity with the functional groups present in the minor and major grooves of particular DNA sequences. Specific hydrogen bonding patterns are particularly useful for the purpose of sequence recognition. Less obvious, however, is the influence of base composition on the conforma...
متن کاملDNA electrochemistry as a probe of base pair stacking in A-, B-, and Z-form DNA.
DNA-mediated charge transport (CT) chemistry is sensitive to DNA structure and base pair stacking. In an electrochemical assay based upon DNA CT, DNA-modified electrode surfaces are used to examine the electrochemical reduction of methylene blue (MB), a small molecule that binds to the DNA film by intercalation. Here electrochemically we probe CT in the three primary conformations of double-str...
متن کاملCharge transport in DNA.
The base pair stack within double helical DNA provides an effective medium for charge transport. The DNA pi-stack mediates oxidative DNA damage over long molecular distances in a reaction that is exquisitely sensitive to the sequence-dependent conformation and dynamics of DNA. A mixture of tunneling and hopping mechanisms have been proposed to account for this long-range chemistry, which is gat...
متن کاملMolecular dynamics of a κB DNA element: base flipping via cross-strand intercalative stacking in a microsecond-scale simulation
The sequence-dependent structural variability and conformational dynamics of DNA play pivotal roles in many biological milieus, such as in the site-specific binding of transcription factors to target regulatory elements. To better understand DNA structure, function, and dynamics in general, and protein...DNA recognition in the 'kappaB' family of genetic regulatory elements in particular, we per...
متن کاملLong-range DNA charge transport.
The stack of base pairs within double helical DNA has been shown to mediate charge transport reactions. Charge transport through DNA can result in chemistry at a distance, yielding oxidative DNA damage at a site remote from the bound oxidant. Since DNA charge transport chemistry depends on coupling within the stacked base pair array, this chemistry is remarkably sensitive to sequence-dependent ...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2003
ISSN: 1520-6106,1520-5207
DOI: 10.1021/jp030753i